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An investigation on the allelic chi-square test used in genetic association studies

Title
An investigation on the allelic chi-square test used in genetic association studies
Authors
Kang S.-H.Shin D.-W.Oh M.-S.Ahn C.W.
Ewha Authors
오만숙신동완강승호
SCOPUS Author ID
오만숙scopus; 신동완scopus
Issue Date
2004
Journal Title
Biometrical Journal
ISSN
0323-3847JCR Link
Citation
Biometrical Journal vol. 46, no. 6, pp. 699 - 706
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Case-control studies are primary study designs used in genetic association studies. Sasieni (Biometrics 1997, 53, 1253-1261) pointed out that the allelic chi-square test used in genetic association studies is invalid when Hardy-Weinberg equilibrium (HWE) is violated in a combined population. It is important to know how much type I error rate is deviated from the nominal level under violated HWE. We examine bounds of type I error rate of the allelic chi-square test. We also investigate power of the goodness-of-fit test for HWE which can be used as a guideline for selecting an appropriate test between the allelic chi-square test and the modified allelic chi-square test, the latter of which was proposed for cases of violated HWE. In small samples, power is not large enough to detect the Wright's inbreeding model of small values of inbreeding coefficient. Therefore, when the null hypothesis of HWE is barely accepted, the modified test should be considered as an alternative method.
DOI
10.1002/bimj.200410063
Appears in Collections:
자연과학대학 > 통계학전공 > Journal papers
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