오만숙
신동완
강승호
2018-05-18T08:15:22Z
2018-05-18T08:15:22Z
2004
0323-3847
OAK-2527
http://dspace.ewha.ac.kr/handle/2015.oak/243242
Case-control studies are primary study designs used in genetic association studies. Sasieni (Biometrics 1997, 53, 1253-1261) pointed out that the allelic chi-square test used in genetic association studies is invalid when Hardy-Weinberg equilibrium (HWE) is violated in a combined population. It is important to know how much type I error rate is deviated from the nominal level under violated HWE. We examine bounds of type I error rate of the allelic chi-square test. We also investigate power of the goodness-of-fit test for HWE which can be used as a guideline for selecting an appropriate test between the allelic chi-square test and the modified allelic chi-square test, the latter of which was proposed for cases of violated HWE. In small samples, power is not large enough to detect the Wright's inbreeding model of small values of inbreeding coefficient. Therefore, when the null hypothesis of HWE is barely accepted, the modified test should be considered as an alternative method.
English
An investigation on the allelic chi-square test used in genetic association studies
Article
6
46
SCIE
SCOPUS
699
706
Biometrical Journal
10.1002/bimj.200410063
WOS:000226083300007
2-s2.0-11844271502
Kang S.-H.
Shin D.-W.
Oh M.-S.
Ahn C.W.
오만숙(7201600334)
신동완(7403352539)
20180517113950