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Enhanced intracellular delivery of macromolecules by melittin derivatives mediated cellular uptake

Title
Enhanced intracellular delivery of macromolecules by melittin derivatives mediated cellular uptake
Authors
Kyung, HeiwonKim, HeejungLee, HyukjinLee, Seung Jin
Ewha Authors
이승진김희정이혁진
SCOPUS Author ID
이승진scopus; 김희정scopusscopusscopus; 이혁진scopus
Issue Date
2018
Journal Title
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
ISSN
1226-086XJCR Link

1876-794XJCR Link
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY vol. 58, pp. 290 - 295
Keywords
MelittinCell-penetrating peptideIntracellular delivery
Publisher
ELSEVIER SCIENCE INC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Various cell-penetrating peptides (CPPs) have been utilized as a promising tool for intracellular delivery of therapeutic macromolecules. In this study, hemolytic membrane-active peptide (Melittin) has been utilized for intracellular uptake of macromolecules by its sequential fragmentation. Among its fragmented derivatives, melittin(1-14) showed highly efficient delivery of proteins into HeLa cells, while maintaining their biological activities. The highest level of intracellular delivery was observed when beta-galactosidase and Cytochrome C were co-delivered with melittin(1-14). These data suggested that melittin(1-14) could be a useful adjuvant for the enhanced intracellular delivery of therapeutic macromolecules. (C) 2017 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.
DOI
10.1016/j.jiec.2017.09.039
Appears in Collections:
약학대학 > 약학과 > Journal papers
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