Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | * |
dc.contributor.author | 김희정 | * |
dc.contributor.author | 이혁진 | * |
dc.date.accessioned | 2018-04-25T08:13:36Z | - |
dc.date.available | 2018-04-25T08:13:36Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1226-086X | * |
dc.identifier.issn | 1876-794X | * |
dc.identifier.other | OAK-22026 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242553 | - |
dc.description.abstract | Various cell-penetrating peptides (CPPs) have been utilized as a promising tool for intracellular delivery of therapeutic macromolecules. In this study, hemolytic membrane-active peptide (Melittin) has been utilized for intracellular uptake of macromolecules by its sequential fragmentation. Among its fragmented derivatives, melittin(1-14) showed highly efficient delivery of proteins into HeLa cells, while maintaining their biological activities. The highest level of intracellular delivery was observed when beta-galactosidase and Cytochrome C were co-delivered with melittin(1-14). These data suggested that melittin(1-14) could be a useful adjuvant for the enhanced intracellular delivery of therapeutic macromolecules. (C) 2017 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE INC | * |
dc.subject | Melittin | * |
dc.subject | Cell-penetrating peptide | * |
dc.subject | Intracellular delivery | * |
dc.title | Enhanced intracellular delivery of macromolecules by melittin derivatives mediated cellular uptake | * |
dc.type | Article | * |
dc.relation.volume | 58 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 290 | * |
dc.relation.lastpage | 295 | * |
dc.relation.journaltitle | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | * |
dc.identifier.doi | 10.1016/j.jiec.2017.09.039 | * |
dc.identifier.wosid | WOS:000424182500037 | * |
dc.identifier.scopusid | 2-s2.0-85033224155 | * |
dc.author.google | Kyung, Heiwon | * |
dc.author.google | Kim, Heejung | * |
dc.author.google | Lee, Hyukjin | * |
dc.author.google | Lee, Seung Jin | * |
dc.contributor.scopusid | 이승진(57196249292) | * |
dc.contributor.scopusid | 김희정(57206210649) | * |
dc.contributor.scopusid | 이혁진(55233457200) | * |
dc.date.modifydate | 20240220111730 | * |