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Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities

Title
Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities
Authors
Tikum, Anjong FlorenceJeon, Yu JeongLee, Ju HyunPark, Min HeeBaea, In YeongKim, Sang HeonLee, Hye JinKim, Jinheung
Ewha Authors
김진흥
SCOPUS Author ID
김진흥scopus
Issue Date
2018
Journal Title
JOURNAL OF INORGANIC BIOCHEMISTRY
ISSN
0162-0134JCR Link

1873-3344JCR Link
Citation
JOURNAL OF INORGANIC BIOCHEMISTRY vol. 180, pp. 204 - 210
Keywords
Polypyridyl ruthenium complexCytotoxic activityCellular uptakeAnticancer activityCell migration
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Three ruthenium complexes containing a bidentate piq ligand, [(piq)Ru(bpy)(2)](2+) (1), [(piq)Ru(phen)(2)](2+) (2), and [(piq)Ru(DIP)(2)](2+). (3) (piq = phenylisoquinolinate, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, DIP = 4,7-dipheny1-1,10-phenanthroline), were prepared. The DNA binding properties of complexes 1-3 to double-stranded DNA were studied. The binding of 1-3 to calf-thymus DNA (ct-DNA) yielded lower emission intensities than those observed with the corresponding Ru complexes alone. To explore potential interactions of complexes 1-3 with lipid-rich organs in live cells, the emission properties of the Ru probes were studied with liposomes. The emission intensities of complexes 1-3 were enhanced to similar extents upon interaction with liposomes. The cytotoxic activities of the complexes against MDA-MB-231 and HUVECs were evaluated in vitro. The effects of complexes 1-3 on the survival of MDA-MB-231 cells were examined and compared with that of cisplatin. Complexes 2 and 3 were more cytotoxic to cancer cells than cis-platin. Complexes 1-3 showed cellular uptakes of 1.1, 10.6, and 76.6%, respectively, indicating that the greatest amount of complex 3 entered the cancer cells. Inhibition of cell migration by complexes 1-3 was also evaluated by the wound healing assay.
DOI
10.1016/j.jinorgbio.2018.01.003
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자연과학대학 > 화학·나노과학전공 > Journal papers
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