Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김진흥 | - |
dc.date.accessioned | 2018-04-25T08:13:14Z | - |
dc.date.available | 2018-04-25T08:13:14Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0162-0134 | - |
dc.identifier.issn | 1873-3344 | - |
dc.identifier.other | OAK-22261 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242426 | - |
dc.description.abstract | Three ruthenium complexes containing a bidentate piq ligand, [(piq)Ru(bpy)(2)](2+) (1), [(piq)Ru(phen)(2)](2+) (2), and [(piq)Ru(DIP)(2)](2+). (3) (piq = phenylisoquinolinate, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, DIP = 4,7-dipheny1-1,10-phenanthroline), were prepared. The DNA binding properties of complexes 1-3 to double-stranded DNA were studied. The binding of 1-3 to calf-thymus DNA (ct-DNA) yielded lower emission intensities than those observed with the corresponding Ru complexes alone. To explore potential interactions of complexes 1-3 with lipid-rich organs in live cells, the emission properties of the Ru probes were studied with liposomes. The emission intensities of complexes 1-3 were enhanced to similar extents upon interaction with liposomes. The cytotoxic activities of the complexes against MDA-MB-231 and HUVECs were evaluated in vitro. The effects of complexes 1-3 on the survival of MDA-MB-231 cells were examined and compared with that of cisplatin. Complexes 2 and 3 were more cytotoxic to cancer cells than cis-platin. Complexes 1-3 showed cellular uptakes of 1.1, 10.6, and 76.6%, respectively, indicating that the greatest amount of complex 3 entered the cancer cells. Inhibition of cell migration by complexes 1-3 was also evaluated by the wound healing assay. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | Polypyridyl ruthenium complex | - |
dc.subject | Cytotoxic activity | - |
dc.subject | Cellular uptake | - |
dc.subject | Anticancer activity | - |
dc.subject | Cell migration | - |
dc.title | Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities | - |
dc.type | Article | - |
dc.relation.volume | 180 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 204 | - |
dc.relation.lastpage | 210 | - |
dc.relation.journaltitle | JOURNAL OF INORGANIC BIOCHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jinorgbio.2018.01.003 | - |
dc.identifier.wosid | WOS:000426621000023 | - |
dc.identifier.scopusid | 2-s2.0-85044371621 | - |
dc.author.google | Tikum, Anjong Florence | - |
dc.author.google | Jeon, Yu Jeong | - |
dc.author.google | Lee, Ju Hyun | - |
dc.author.google | Park, Min Hee | - |
dc.author.google | Baea, In Yeong | - |
dc.author.google | Kim, Sang Heon | - |
dc.author.google | Lee, Hye Jin | - |
dc.author.google | Kim, Jinheung | - |
dc.contributor.scopusid | 김진흥(8580015800) | - |
dc.date.modifydate | 20230201114415 | - |