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Acute and 13-week subchronic toxicological evaluations of turanose in mice

Title
Acute and 13-week subchronic toxicological evaluations of turanose in mice
Authors
Chung J.-Y.Lee J.Lee D.Kim E.Shin J.-H.Seok P.R.Yoo S.-H.Kim Y.
Ewha Authors
김유리
SCOPUS Author ID
김유리scopus
Issue Date
2017
Journal Title
Nutrition Research and Practice
ISSN
1976-1457JCR Link
Citation
vol. 11, no. 6, pp. 452 - 460
Keywords
ICR miceLD50NOAELToxicityTuranose
Publisher
Korean Nutrition Society
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
BACKGROUD/OBJECTIVES: Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice. MATERIALS AND METHODS: For the acute oral toxicity study, turanose was administered as a single oral dose [10 g/kg body weight (b.w.)]. In the subchronic toxicity study, ICR mice were administered 0, 1.75, 3.5, and 7 g/kg b.w. doses of turanose daily for 13 weeks. RESULTS: No signs of acute toxicity, including abnormal behavior, adverse effect, or mortality, were observed over the 14-day study period. In addition, no changes in body weight or food consumption were observed and the median lethal dose (LD) for oral intake of turanose was determined to be greater than 10 g/kg b.w. General clinical behavior, changes in body weight and food consumption, absolute and relative organ weights, and mortality were not affected in any of the treatment group for 13 weeks. These doses also did not affect the macroscopic pathology, histology, hematology, and blood biochemical analysis of the mice examined. CONCLUSION: No toxicity was observed in the acute and 13-week subchronic oral toxicology studies that were conducted with ICR mice. Furthermore, the no-observed-adverse-effect level is greater than 7 g/kg/day for both male and female ICR mice. © 2017 The Korean Nutrition Society and the Korean Society of Community Nutrition.
DOI
10.4162/nrp.2017.11.6.452
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신산업융합대학 > 식품영양학과 > Journal papers
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