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A standardized extract of the fruit of Hovenia dulcis alleviated alcohol-induced hangover in healthy subjects with heterozygous ALDH2: A randomized, controlled, crossover trial

Title
A standardized extract of the fruit of Hovenia dulcis alleviated alcohol-induced hangover in healthy subjects with heterozygous ALDH2: A randomized, controlled, crossover trial
Authors
Kim H.Kim Y.J.Jeong H.Y.Kim J.Y.Choi E.-K.Chae S.W.Kwon O.
Ewha Authors
권오란김지연
SCOPUS Author ID
권오란scopus
Issue Date
2017
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741JCR Link
Citation
vol. 209, pp. 167 - 174
Keywords
AlcoholFruit of Hovenia dulcis ThunbGenetic polymorphismHangoverInflammation
Publisher
Elsevier Ireland Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Ethnopharmacological relevance Hovenia dulcis, known as the oriental raisin tree, is mainly found in East Asia. It has long been used as traditional folk remedies for alcohol intoxication. Aim of the study To examine the anti-hangover effect of Hovenia dulcis Thunb. fruit extract (HDE) in a randomized controlled crossover trial. Materials and methods Twenty-six eligible male adults with heterozygous ALDH2 (23.7±0.3 years old) consumed 360 mL of Korean Soju (50 g alcohol) together with HDE (2460 mg) or matched placebo with subsequent crossover. The blood samples were taken at baseline and 1, 4, and 12 h post-treatment. Results Blood alcohol, acetaldehyde, and total hangover scores were highest at 1 h post-treatment with no difference between groups, but declines in hangover symptom scores were significant in the HDE group compared to the placebo group. Significant differences between groups were also observed on interleukin (IL)-6, IL-10, IL-10/IL-6 ratio, and aspartate aminotransferase levels, but not on endotoxins. Pearson correlation analysis revealed a positive correlation between total hangover symptom scores and IL-6 and IL-10 level. Further analyses by CYP2E1 polymorphism at rs10776687, rs2031920, rs3813867, and rs4838767 alleles showed a reversed association, suggesting that CYP2E1 polymorphism might be an effect modifier. Conclusions The results suggest that a favorable effect of HDE on alcohol hangovers might be associated with enhancing homeostatic regulation of inflammatory response. The magnitude of impact might be different in the presence of CYP2E1 polymorphism. © 2017 Elsevier Ireland Ltd
DOI
10.1016/j.jep.2017.07.028
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신산업융합대학 > 식품영양학과 > Journal papers
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