Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2017-12-27T16:31:05Z | - |
dc.date.available | 2017-12-27T16:31:05Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2072-6643 | * |
dc.identifier.other | OAK-21423 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239417 | - |
dc.description.abstract | Phyllodulcin is a natural sweetener found in Hydrangea macrophylla var. thunbergii. This study investigated whether phyllodulcin could improve metabolic abnormalities in high-fat diet (HFD)-induced obese mice. Animals were fed a 60% HFD for 6 weeks to induce obesity, followed by 7 weeks of supplementation with phyllodulcin (20 or 40 mg/kg body weight (b.w.)/day). Stevioside (40 mg/kg b.w./day) was used as a positive control. Phyllodulcin supplementation reduced subcutaneous fat mass, levels of plasma lipids, triglycerides, total cholesterol, and low-density lipoprotein cholesterol and improved the levels of leptin, adiponectin, and fasting blood glucose. In subcutaneous fat tissues, supplementation with stevioside or phyllodulcin significantly decreased mRNA expression of lipogenesis-related genes, including CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferator activated receptor γ (PPARγ), and sterol regulatory element-binding protein-1C (SREBP-1c) compared to the high-fat group. Phyllodulcin supplementation significantly increased the expression of fat browning-related genes, including PR domain containing 16 (Prdm16), uncoupling protein 1 (UCP1), and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), compared to the high-fat group. Hypothalamic brain-derived neurotrophic factor-tropomyosin receptor kinase B (BDNF-TrkB) signaling was upregulated by phyllodulcin supplementation. In conclusion, phyllodulcin is a potential sweetener that could be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | Adipogenesis | * |
dc.subject | BDNF-TrkB | * |
dc.subject | Fat browning | * |
dc.subject | High fat diet | * |
dc.subject | Hypothalamus | * |
dc.subject | Obesity | * |
dc.subject | Phyllodulcin | * |
dc.subject | Subcutaneous fat | * |
dc.title | Phyllodulcin, a natural sweetener, regulates obesity-related metabolic changes and fat browning-related genes of subcutaneous white adipose tissue in high-fat diet-induced obese mice | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Nutrients | * |
dc.identifier.doi | 10.3390/nu9101049 | * |
dc.identifier.wosid | WOS:000414629900005 | * |
dc.identifier.scopusid | 2-s2.0-85030114375 | * |
dc.author.google | Kim E. | * |
dc.author.google | Lim S.-M. | * |
dc.author.google | Kim M.-S. | * |
dc.author.google | Yoo S.-H. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |