Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오란 | * |
dc.date.accessioned | 2017-10-27T11:45:32Z | - |
dc.date.available | 2017-10-27T11:45:32Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0753-3322 | * |
dc.identifier.other | OAK-20771 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237232 | - |
dc.description.abstract | Abnormalities in the hyperbolic relationship between insulin sensitivity and insulin secretion may cause oxidative stress and non-enzymatic glycation, resulting in an increased risk of type 2 diabetes. Here, we performed a 14-week study to investigate the effects of ethanolic extract of Mori ramulus (MRE; 0, 800, and 1600 mg/kg body weight) and its signature component oxyresveratrol (OXY; 800 mg/kg body weight) on β-cell dysfunction and insulin resistance in C57BLKS/J db/db mice fed with a high-fat diet. Compared with the diabetic control group, the high-dose MRE group showed a significant decrease in fasting blood glucose (p = 0.0024); a significant increase in insulin secretion as measured by insulin (p = 0.0012) and C-peptide (p = 0.0103) levels in plasma and insulin content (p = 0.0440) and homeobox factor-1 protein expression (p = 0.0148) in the pancreas; and a significant increase in insulin sensitivity as measured by insulin receptor mRNA expression in the liver (p = 0.0179) and adipose tissue (p = 0.0491). In addition, improvements in the reactive oxygen species level and inflammatory pancreatic and hepatic tissue damage were also observed in the MRE group as assessed by histological findings. A similar but weaker effect was found in the OXY group. Furthermore, we observed a potentiating effect of MRE and OXY on insulin secretion in INS-1 cells in the presence of 27 mM glucose, together with an anti-glycation effect as indicated by methylglyoxal-trapping capacity and inhibition of advanced glycation end-product formation. Taken together, these data suggest that MRE could ameliorate β-cell dysfunction and insulin resistance by reducing oxidative damage and advanced glycation end-product (Wagenknecht et al., 2003) formation and that these effects are due, at least in part, to OXY. © 2017 Elsevier Masson SAS | * |
dc.language | English | * |
dc.publisher | Elsevier Masson SAS | * |
dc.subject | Advanced glycation end-products | * |
dc.subject | Hyperglycemia | * |
dc.subject | Insulin resistance | * |
dc.subject | Mori ramulus | * |
dc.subject | Oxyresveratrol | * |
dc.subject | Pancreatic β-cell dysfunction | * |
dc.title | Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells | * |
dc.type | Article | * |
dc.relation.volume | 92 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 308 | * |
dc.relation.lastpage | 315 | * |
dc.relation.journaltitle | Biomedicine and Pharmacotherapy | * |
dc.identifier.doi | 10.1016/j.biopha.2017.05.080 | * |
dc.identifier.wosid | WOS:000407915600036 | * |
dc.identifier.scopusid | 2-s2.0-85019882967 | * |
dc.author.google | Park S.-Y. | * |
dc.author.google | Jin B. | * |
dc.author.google | Shin J.-H. | * |
dc.author.google | Adisakwattana S. | * |
dc.author.google | Kwon O. | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.date.modifydate | 20240123125010 | * |