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The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Title
The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection
Authors
Choi S.-K.Mun G.-I.Choi E.Kim S.-Y.Kwon Y.Na Y.Lee Y.-S.
Ewha Authors
권영주이윤실
SCOPUS Author ID
권영주scopus; 이윤실scopus
Issue Date
2017
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 80, no. 8, pp. 2379 - 2383
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation. © 2017 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/acs.jnatprod.7b00126
Appears in Collections:
약학대학 > 약학과 > Journal papers
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