Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2017-10-27T11:45:00Z | - |
dc.date.available | 2017-10-27T11:45:00Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.other | OAK-21251 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237080 | - |
dc.description.abstract | Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation. © 2017 The American Chemical Society and American Society of Pharmacognosy. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.title | The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 80 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2379 | * |
dc.relation.lastpage | 2383 | * |
dc.relation.journaltitle | Journal of Natural Products | * |
dc.identifier.doi | 10.1021/acs.jnatprod.7b00126 | * |
dc.identifier.wosid | WOS:000408702600023 | * |
dc.identifier.scopusid | 2-s2.0-85028331690 | * |
dc.author.google | Choi S.-K. | * |
dc.author.google | Mun G.-I. | * |
dc.author.google | Choi E. | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Na Y. | * |
dc.author.google | Lee Y.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |