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dc.contributor.author권영주*
dc.contributor.author이윤실*
dc.date.accessioned2017-10-27T11:45:00Z-
dc.date.available2017-10-27T11:45:00Z-
dc.date.issued2017*
dc.identifier.issn0163-3864*
dc.identifier.otherOAK-21251*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/237080-
dc.description.abstractConiferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation. © 2017 The American Chemical Society and American Society of Pharmacognosy.*
dc.languageEnglish*
dc.publisherAmerican Chemical Society*
dc.titleThe Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection*
dc.typeArticle*
dc.relation.issue8*
dc.relation.volume80*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage2379*
dc.relation.lastpage2383*
dc.relation.journaltitleJournal of Natural Products*
dc.identifier.doi10.1021/acs.jnatprod.7b00126*
dc.identifier.wosidWOS:000408702600023*
dc.identifier.scopusid2-s2.0-85028331690*
dc.author.googleChoi S.-K.*
dc.author.googleMun G.-I.*
dc.author.googleChoi E.*
dc.author.googleKim S.-Y.*
dc.author.googleKwon Y.*
dc.author.googleNa Y.*
dc.author.googleLee Y.-S.*
dc.contributor.scopusid권영주(12446435600)*
dc.contributor.scopusid이윤실(17137192000)*
dc.date.modifydate20240130115944*
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약학대학 > 약학과 > Journal papers
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