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Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.

Title
Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.
Authors
Kim, KyuriLeutou, Alain S.Jeong, HaeinKim, DayoungSeong, Chi NamNam, Sang-JipLim, Kyung-Min
Ewha Authors
임경민남상집
SCOPUS Author ID
임경민scopus; 남상집scopus
Issue Date
2017
Journal Title
MARINE DRUGS
ISSN
1660-3397JCR Link
Citation
vol. 15, no. 5
Keywords
Bacillus sp.(-)-4-hydroxysattabacinmelanogenesismarine-derivedanti-pigmentary effect
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT-PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, Melanoderm (TM), and manifested as whitening and regression of melanocyte activation in the tissue.
DOI
10.3390/md15050138
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약학대학 > 약학과 > Journal papers
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