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Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.
- Title
- Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.
- Authors
- Kim, Kyuri; Leutou, Alain S.; Jeong, Haein; Kim, Dayoung; Seong, Chi Nam; Nam, Sang-Jip; Lim, Kyung-Min
- Ewha Authors
- 임경민; 남상집
- SCOPUS Author ID
- 임경민; 남상집
- Issue Date
- 2017
- Journal Title
- MARINE DRUGS
- ISSN
- 1660-3397
- Citation
- MARINE DRUGS vol. 15, no. 5
- Keywords
- Bacillus sp.; (-)-4-hydroxysattabacin; melanogenesis; marine-derived; anti-pigmentary effect
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT-PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, Melanoderm (TM), and manifested as whitening and regression of melanocyte activation in the tissue.
- DOI
- 10.3390/md15050138
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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