Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임경민 | * |
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2017-07-04T01:07:57Z | - |
dc.date.available | 2017-07-04T01:07:57Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-20754 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235466 | - |
dc.description.abstract | Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT-PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, Melanoderm (TM), and manifested as whitening and regression of melanocyte activation in the tissue. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | Bacillus sp. | * |
dc.subject | (-)-4-hydroxysattabacin | * |
dc.subject | melanogenesis | * |
dc.subject | marine-derived | * |
dc.subject | anti-pigmentary effect | * |
dc.title | Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp. | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MARINE DRUGS | * |
dc.identifier.doi | 10.3390/md15050138 | * |
dc.identifier.wosid | WOS:000404235100014 | * |
dc.identifier.scopusid | 2-s2.0-85019639772 | * |
dc.author.google | Kim, Kyuri | * |
dc.author.google | Leutou, Alain S. | * |
dc.author.google | Jeong, Haein | * |
dc.author.google | Kim, Dayoung | * |
dc.author.google | Seong, Chi Nam | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Lim, Kyung-Min | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220115649 | * |