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Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics
- Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics
- Park J.W.; Nam S.-J.; Yoon Y.J.
- Ewha Authors
- 윤여준; 남상집
- SCOPUS Author ID
- 윤여준; 남상집
- Issue Date
- Journal Title
- Biochemical Pharmacology
- vol. 134, pp. 56 - 73
- Anti-infective and anti-proliferative; Combinatorial biosynthesis; Sugar-containing antibiotics
- Elsevier Inc.
- SCI; SCIE; SCOPUS
- Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era. © 2016 Elsevier Inc.
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- 자연과학대학 > 화학·나노과학전공 > Journal papers
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