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Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics

Title
Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics
Authors
Park J.W.Nam S.-J.Yoon Y.J.
Ewha Authors
윤여준남상집
SCOPUS Author ID
윤여준scopus; 남상집scopus
Issue Date
2017
Journal Title
Biochemical Pharmacology
ISSN
0006-2952JCR Link
Citation
vol. 134, pp. 56 - 73
Keywords
Anti-infective and anti-proliferativeCombinatorial biosynthesisSugar-containing antibiotics
Publisher
Elsevier Inc.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era. © 2016 Elsevier Inc.
DOI
10.1016/j.bcp.2016.10.009
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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