Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | * |
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2017-05-30T01:05:22Z | - |
dc.date.available | 2017-05-30T01:05:22Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0006-2952 | * |
dc.identifier.other | OAK-20570 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235208 | - |
dc.description.abstract | Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era. © 2016 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Elsevier Inc. | * |
dc.subject | Anti-infective and anti-proliferative | * |
dc.subject | Combinatorial biosynthesis | * |
dc.subject | Sugar-containing antibiotics | * |
dc.title | Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics | * |
dc.type | Review | * |
dc.relation.volume | 134 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 56 | * |
dc.relation.lastpage | 73 | * |
dc.relation.journaltitle | Biochemical Pharmacology | * |
dc.identifier.doi | 10.1016/j.bcp.2016.10.009 | * |
dc.identifier.wosid | WOS:000401684700005 | * |
dc.identifier.scopusid | 2-s2.0-85005784386 | * |
dc.author.google | Park J.W. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Yoon Y.J. | * |
dc.contributor.scopusid | 윤여준(7402126465) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |