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GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase

Title
GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase
Authors
Na, Jung-HyunAn, Young JunCha, Sun-Shin
Ewha Authors
차선신
SCOPUS Author ID
차선신scopus
Issue Date
2017
Journal Title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN
0066-4804JCR Link1098-6596JCR Link
Citation
vol. 61, no. 5
Keywords
GMPIMPbeta-lactamasescompetitive inhibitor
Publisher
AMER SOC MICROBIOLOGY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nucleotides were effective in inhibiting the class C beta-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a K-i value of 16.2 mu M. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent.
DOI
10.1128/AAC.00098-17
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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