DSpace at EWHA: GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase

View : 913 Download: 309

Full metadata record

DC Field	Value	Language
dc.contributor.author	차선신	*
dc.date.accessioned	2017-05-30T01:05:21Z	-
dc.date.available	2017-05-30T01:05:21Z	-
dc.date.issued	2017	*
dc.identifier.issn	0066-4804	*
dc.identifier.issn	1098-6596	*
dc.identifier.other	OAK-20575	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/235204	-
dc.description.abstract	Nucleotides were effective in inhibiting the class C beta-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a K-i value of 16.2 mu M. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent.	*
dc.language	English	*
dc.publisher	AMER SOC MICROBIOLOGY	*
dc.subject	GMP	*
dc.subject	IMP	*
dc.subject	beta-lactamases	*
dc.subject	competitive inhibitor	*
dc.title	GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase	*
dc.type	Article	*
dc.relation.issue	5	*
dc.relation.volume	61	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.journaltitle	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY	*
dc.identifier.doi	10.1128/AAC.00098-17	*
dc.identifier.wosid	WOS:000403532100010	*
dc.identifier.scopusid	2-s2.0-85018186854	*
dc.author.google	Na, Jung-Hyun	*
dc.author.google	An, Young Jun	*
dc.author.google	Cha, Sun-Shin	*
dc.contributor.scopusid	차선신(7201864593)	*
dc.date.modifydate	20240429134916	*