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Pharmacokinetics of doxazosin gastrointestinal therapeutic system after multiple administration in Korean healthy volunteers

Title
Pharmacokinetics of doxazosin gastrointestinal therapeutic system after multiple administration in Korean healthy volunteers
Authors
Kwon Y.H.Gwak H.S.Yoon S.J.Chun I.K.
Ewha Authors
곽혜선
SCOPUS Author ID
곽혜선scopus
Issue Date
2007
Journal Title
Drug Development and Industrial Pharmacy
ISSN
0363-9045JCR Link
Citation
vol. 33, no. 8, pp. 824 - 829
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Doxazosin mesylate is a selective alpha-adrenoreceptor antagonist for the treatment of hypertension and benign prostatic hyperplasia. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of doxazosin in plasma. A reversed phase C18 column was used for the separation of doxazosin and prazosin (internal standard) with a mobile phase composed of water • acetonitrile • triethylamine (68:32:0.2 v/v, pH 5.0) at a flow rate of 1.2 mL/min. The fluorescence detector was operated at 246 (excitation) and 389 nm (emission). Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 1 ng/mL. Recovery of doxazosin from human plasma was greater than 93.4%. Doxazosin was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of multiple 4-mg dose of doxazosin gastrointestinal therapeutic system formulation to 16 healthy volunteers. At steady state the mean area under the curve for a dosing interval and elimination half-life were calculated to be 367.0 ± 63.5 ng·hr/mL and 29.2 ± 4.5 hr, respectively. There was no difference in pharmacokinetic parameters between male and female. Copyright © Informa Healthcare USA, Inc.
DOI
10.1080/03639040601012999
Appears in Collections:
약학대학 > 약학과 > Journal papers
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