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dc.contributor.author곽혜선-
dc.date.accessioned2017-08-28T11:36:19Z-
dc.date.available2017-08-28T11:36:19Z-
dc.date.issued2007-
dc.identifier.issn0363-9045-
dc.identifier.otherOAK-4260-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/234456-
dc.description.abstractDoxazosin mesylate is a selective alpha-adrenoreceptor antagonist for the treatment of hypertension and benign prostatic hyperplasia. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of doxazosin in plasma. A reversed phase C18 column was used for the separation of doxazosin and prazosin (internal standard) with a mobile phase composed of water • acetonitrile • triethylamine (68:32:0.2 v/v, pH 5.0) at a flow rate of 1.2 mL/min. The fluorescence detector was operated at 246 (excitation) and 389 nm (emission). Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 1 ng/mL. Recovery of doxazosin from human plasma was greater than 93.4%. Doxazosin was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of multiple 4-mg dose of doxazosin gastrointestinal therapeutic system formulation to 16 healthy volunteers. At steady state the mean area under the curve for a dosing interval and elimination half-life were calculated to be 367.0 ± 63.5 ng·hr/mL and 29.2 ± 4.5 hr, respectively. There was no difference in pharmacokinetic parameters between male and female. Copyright © Informa Healthcare USA, Inc.-
dc.languageEnglish-
dc.titlePharmacokinetics of doxazosin gastrointestinal therapeutic system after multiple administration in Korean healthy volunteers-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume33-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage824-
dc.relation.lastpage829-
dc.relation.journaltitleDrug Development and Industrial Pharmacy-
dc.identifier.doi10.1080/03639040601012999-
dc.identifier.wosidWOS:000249247000003-
dc.identifier.scopusid2-s2.0-34548299764-
dc.author.googleKwon Y.H.-
dc.author.googleGwak H.S.-
dc.author.googleYoon S.J.-
dc.author.googleChun I.K.-
dc.contributor.scopusid곽혜선(6601996377)-
dc.date.modifydate20190901081003-
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약학대학 > 약학과 > Journal papers
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