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Effects of KTJ740, a novel antithrombotic agent, on platelet-derived growth factor-induced rat aortic smooth muscle cell proliferation and cell cycle progression
- Title
- Effects of KTJ740, a novel antithrombotic agent, on platelet-derived growth factor-induced rat aortic smooth muscle cell proliferation and cell cycle progression
- Authors
- Kim T.-J.; Jeon J.; Jin Y.-R.; Son D.-J.; Yoo H.-S.; Hong J.-T.; Ryu C.-K.; Shin H.-S.; Lee K.-H.; Yun Y.-P.
- Ewha Authors
- 유충규
- SCOPUS Author ID
- 유충규
- Issue Date
- 2007
- Journal Title
- Journal of Cardiovascular Pharmacology
- ISSN
- 0160-2446
- Citation
- Journal of Cardiovascular Pharmacology vol. 49, no. 5, pp. 280 - 286
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Hyperproliferation of platelet-derived growth factor (PDGF)-BB-induced vascular smooth muscle cell (VSMC) is a hallmark of atherosclerosis and related vascular disorders. In the previous study, we reported that KTJ740 [2-chloro-3-(4-(ethylcarboxy)-phenyl)-amino-1,4-naphthoquinone], a newly synthesized vitamin K derivative, has potent antithrombotic effects in mice and antiplatelet activity in vitro and ex vivo. In the present study, we have tested that KTJ740 could inhibit PDGF-BB-stimulated VSMC proliferation. We have examined the potential inhibitory effect of this compound on rat aortic smooth muscle cells (RASMCs). Our results show that this compound significantly inhibits PDGF-BB-stimulated RASMC number and DNA synthesis in a concentration-dependent manner. Furthermore, we have examined its effect on cell cycle progression by flow cytometry. KTJ740 treatment resulted in a significant arrest in cell cycle progression of RASMCs induced by PDGF-BB, and this effect was achieved by suppressing activation of PDGF-β receptor (PDGF-Rβ) tyrosine kinase pathway. These results suggest that a possibility of KTJ740 can be a potential agent to control vascular disorders and its antiproliferative mechanism may be mediated through PDGF-Rβ tyrosine kinase-dependent signaling pathway. © 2007 Lippincott Williams & Wilkins, Inc.
- DOI
- 10.1097/FJC.0b013e3180399448
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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