Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2017-02-15T08:02:19Z | - |
dc.date.available | 2017-02-15T08:02:19Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0160-2446 | - |
dc.identifier.other | OAK-4022 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234343 | - |
dc.description.abstract | Hyperproliferation of platelet-derived growth factor (PDGF)-BB-induced vascular smooth muscle cell (VSMC) is a hallmark of atherosclerosis and related vascular disorders. In the previous study, we reported that KTJ740 [2-chloro-3-(4-(ethylcarboxy)-phenyl)-amino-1,4-naphthoquinone], a newly synthesized vitamin K derivative, has potent antithrombotic effects in mice and antiplatelet activity in vitro and ex vivo. In the present study, we have tested that KTJ740 could inhibit PDGF-BB-stimulated VSMC proliferation. We have examined the potential inhibitory effect of this compound on rat aortic smooth muscle cells (RASMCs). Our results show that this compound significantly inhibits PDGF-BB-stimulated RASMC number and DNA synthesis in a concentration-dependent manner. Furthermore, we have examined its effect on cell cycle progression by flow cytometry. KTJ740 treatment resulted in a significant arrest in cell cycle progression of RASMCs induced by PDGF-BB, and this effect was achieved by suppressing activation of PDGF-β receptor (PDGF-Rβ) tyrosine kinase pathway. These results suggest that a possibility of KTJ740 can be a potential agent to control vascular disorders and its antiproliferative mechanism may be mediated through PDGF-Rβ tyrosine kinase-dependent signaling pathway. © 2007 Lippincott Williams & Wilkins, Inc. | - |
dc.language | English | - |
dc.title | Effects of KTJ740, a novel antithrombotic agent, on platelet-derived growth factor-induced rat aortic smooth muscle cell proliferation and cell cycle progression | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 49 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 280 | - |
dc.relation.lastpage | 286 | - |
dc.relation.journaltitle | Journal of Cardiovascular Pharmacology | - |
dc.identifier.doi | 10.1097/FJC.0b013e3180399448 | - |
dc.identifier.wosid | WOS:000246782100005 | - |
dc.identifier.scopusid | 2-s2.0-34249805692 | - |
dc.author.google | Kim T.-J. | - |
dc.author.google | Jeon J. | - |
dc.author.google | Jin Y.-R. | - |
dc.author.google | Son D.-J. | - |
dc.author.google | Yoo H.-S. | - |
dc.author.google | Hong J.-T. | - |
dc.author.google | Ryu C.-K. | - |
dc.author.google | Shin H.-S. | - |
dc.author.google | Lee K.-H. | - |
dc.author.google | Yun Y.-P. | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20170901081001 | - |