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Thermosensitive and biocompatible cyclotriphosphazene micelles

Title
Thermosensitive and biocompatible cyclotriphosphazene micelles
Authors
Toti U.S.Moon S.H.Kim H.Y.Jun Y.J.Kim B.M.Park Y.M.Jeong B.Sohn Y.S.
Ewha Authors
손연수정병문
SCOPUS Author ID
손연수scopus; 정병문scopus
Issue Date
2007
Journal Title
Journal of Controlled Release
ISSN
0168-3659JCR Link
Citation
vol. 119, no. 1, pp. 34 - 40
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new class of thermosensitive micellar cyclotriphosphazenes has been synthesized by stepwise nucleophilic substitutions of hexachlorocyclotriphosphazene with a hydrophilic methoxy poly(ethylene glycol) (MPEG) and a hydrophobic oligopeptide selected from tetra- to hexapeptides, and characterized by means of multinuclear ( 1H, 31P) NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) method. All the amphiphilic trimers were found to form stable micelles by self-assembly in aqueous solution and to exhibit a lower critical solution temperature in the range of 20-48 °C in water depending on the hydrophilic to hydrophobic balance of the side groups. The micelles formed from the trimers bearing MPEG350 and a tetra- or pentapeptide were found to have a mean diameter of 13-14 nm, while, surprisingly, the trimers bearing longer MPEG550 and hexapeptides have shown remarkable contraction of their micelle size to a mean diameter of 7-8 nm, probably due to the strong intermolecular hydrophobic interactions among the hexapeptide groups of the trimers. The local tolerance tests using rabbits have shown excellent biocompatibility of the trimers. Also a promising in vitro releasing profile was obtained for local delivery of human growth hormone (hGH) as a model protein drug. © 2007 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jconrel.2007.01.003
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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