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Thermosensitive and biocompatible cyclotriphosphazene micelles
- Title
- Thermosensitive and biocompatible cyclotriphosphazene micelles
- Authors
- Toti U.S.; Moon S.H.; Kim H.Y.; Jun Y.J.; Kim B.M.; Park Y.M.; Jeong B.; Sohn Y.S.
- Ewha Authors
- 손연수; 정병문
- SCOPUS Author ID
- 손연수; 정병문
- Issue Date
- 2007
- Journal Title
- Journal of Controlled Release
- ISSN
- 0168-3659
- Citation
- Journal of Controlled Release vol. 119, no. 1, pp. 34 - 40
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new class of thermosensitive micellar cyclotriphosphazenes has been synthesized by stepwise nucleophilic substitutions of hexachlorocyclotriphosphazene with a hydrophilic methoxy poly(ethylene glycol) (MPEG) and a hydrophobic oligopeptide selected from tetra- to hexapeptides, and characterized by means of multinuclear ( 1H, 31P) NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) method. All the amphiphilic trimers were found to form stable micelles by self-assembly in aqueous solution and to exhibit a lower critical solution temperature in the range of 20-48 °C in water depending on the hydrophilic to hydrophobic balance of the side groups. The micelles formed from the trimers bearing MPEG350 and a tetra- or pentapeptide were found to have a mean diameter of 13-14 nm, while, surprisingly, the trimers bearing longer MPEG550 and hexapeptides have shown remarkable contraction of their micelle size to a mean diameter of 7-8 nm, probably due to the strong intermolecular hydrophobic interactions among the hexapeptide groups of the trimers. The local tolerance tests using rabbits have shown excellent biocompatibility of the trimers. Also a promising in vitro releasing profile was obtained for local delivery of human growth hormone (hGH) as a model protein drug. © 2007 Elsevier B.V. All rights reserved.
- DOI
- 10.1016/j.jconrel.2007.01.003
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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