Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손연수 | * |
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2017-02-15T08:02:18Z | - |
dc.date.available | 2017-02-15T08:02:18Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0168-3659 | * |
dc.identifier.other | OAK-4016 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234337 | - |
dc.description.abstract | A new class of thermosensitive micellar cyclotriphosphazenes has been synthesized by stepwise nucleophilic substitutions of hexachlorocyclotriphosphazene with a hydrophilic methoxy poly(ethylene glycol) (MPEG) and a hydrophobic oligopeptide selected from tetra- to hexapeptides, and characterized by means of multinuclear ( 1H, 31P) NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) method. All the amphiphilic trimers were found to form stable micelles by self-assembly in aqueous solution and to exhibit a lower critical solution temperature in the range of 20-48 °C in water depending on the hydrophilic to hydrophobic balance of the side groups. The micelles formed from the trimers bearing MPEG350 and a tetra- or pentapeptide were found to have a mean diameter of 13-14 nm, while, surprisingly, the trimers bearing longer MPEG550 and hexapeptides have shown remarkable contraction of their micelle size to a mean diameter of 7-8 nm, probably due to the strong intermolecular hydrophobic interactions among the hexapeptide groups of the trimers. The local tolerance tests using rabbits have shown excellent biocompatibility of the trimers. Also a promising in vitro releasing profile was obtained for local delivery of human growth hormone (hGH) as a model protein drug. © 2007 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Thermosensitive and biocompatible cyclotriphosphazene micelles | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 119 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 34 | * |
dc.relation.lastpage | 40 | * |
dc.relation.journaltitle | Journal of Controlled Release | * |
dc.identifier.doi | 10.1016/j.jconrel.2007.01.003 | * |
dc.identifier.wosid | WOS:000246678100003 | * |
dc.identifier.scopusid | 2-s2.0-34147134533 | * |
dc.author.google | Toti U.S. | * |
dc.author.google | Moon S.H. | * |
dc.author.google | Kim H.Y. | * |
dc.author.google | Jun Y.J. | * |
dc.author.google | Kim B.M. | * |
dc.author.google | Park Y.M. | * |
dc.author.google | Jeong B. | * |
dc.author.google | Sohn Y.S. | * |
dc.contributor.scopusid | 손연수(7201971323) | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |