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약학대학
약학과
Journal papers
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Formulation and evaluation of ketorolac transdermal systems
Title
Formulation and evaluation of ketorolac transdermal systems
Authors
Choi J.S.
;
Cho Y.A.
;
Chun I.K.
;
Jung S.Y.
;
Gwak H.S.
Ewha Authors
곽혜선
Issue Date
2007
Journal Title
Drug Delivery
ISSN
1071-7544
Citation
Drug Delivery vol. 14, no. 2, pp. 69 - 74
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196® showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monocaprylate-DGME (60:40, v/v) revealed the most favorable in vitro and in vivo results. The decreased Cmax and prolonged Tmax and half-life were obtained with the ketorolac transdermal systems compared with oral administration, indicating that the ketorolac transdermal systems may have a prolonged effect with reduced toxic event. There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-∞. Copyright © Informa Healthcare.
DOI
10.1080/10717540600640336
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