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Formulation and evaluation of ketorolac transdermal systems

Title
Formulation and evaluation of ketorolac transdermal systems
Authors
Choi J.S.Cho Y.A.Chun I.K.Jung S.Y.Gwak H.S.
Ewha Authors
곽혜선
SCOPUS Author ID
곽혜선scopus
Issue Date
2007
Journal Title
Drug Delivery
ISSN
1071-7544JCR Link
Citation
vol. 14, no. 2, pp. 69 - 74
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196® showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monocaprylate-DGME (60:40, v/v) revealed the most favorable in vitro and in vivo results. The decreased Cmax and prolonged Tmax and half-life were obtained with the ketorolac transdermal systems compared with oral administration, indicating that the ketorolac transdermal systems may have a prolonged effect with reduced toxic event. There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-∞. Copyright © Informa Healthcare.
DOI
10.1080/10717540600640336
Appears in Collections:
약학대학 > 약학과 > Journal papers
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