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Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt

Title
Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt
Authors
Ko J.H.Yeon S.W.Ryu J.S.Kim T.-Y.Song E.-H.You H.-J.Park R.-E.Ryu C.-K.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2006
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 16, no. 23, pp. 6001 - 6005
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line. © 2006 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2006.08.120
Appears in Collections:
약학대학 > 약학과 > Journal papers
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