DSpace at EWHA: Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt

View : 521 Download: 0

Full metadata record

DC Field	Value	Language
dc.contributor.author	유충규	-
dc.date.accessioned	2017-02-15T08:02:44Z	-
dc.date.available	2017-02-15T08:02:44Z	-
dc.date.issued	2006	-
dc.identifier.issn	0960-894X	-
dc.identifier.other	OAK-3690	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/234173	-
dc.description.abstract	A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line. © 2006 Elsevier Ltd. All rights reserved.	-
dc.language	English	-
dc.title	Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt	-
dc.type	Article	-
dc.relation.issue	23	-
dc.relation.volume	16	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.startpage	6001	-
dc.relation.lastpage	6005	-
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	-
dc.identifier.doi	10.1016/j.bmcl.2006.08.120	-
dc.identifier.wosid	WOS:000242454900014	-
dc.identifier.scopusid	2-s2.0-33750510883	-
dc.author.google	Ko J.H.	-
dc.author.google	Yeon S.W.	-
dc.author.google	Ryu J.S.	-
dc.author.google	Kim T.-Y.	-
dc.author.google	Song E.-H.	-
dc.author.google	You H.-J.	-
dc.author.google	Park R.-E.	-
dc.author.google	Ryu C.-K.	-
dc.contributor.scopusid	유충규(15846918400)	-
dc.date.modifydate	20170901081001	-