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Synthesis and biological evaluation of 5-arylamino-1H-benzo[d]imidazole-4,7-diones as inhibitor of endothelial cell proliferation

Title
Synthesis and biological evaluation of 5-arylamino-1H-benzo[d]imidazole-4,7-diones as inhibitor of endothelial cell proliferation
Authors
Chung K.-H.Hong S.-Y.You H.-J.Park R.-E.Ryu C.-K.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2006
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 14, no. 17, pp. 5795 - 5801
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
5-Arylamino-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activities on the proliferation of human umbilical vein endothelial cells (HUVECs) and the smooth muscle cells (SMCs). Among them, several 1H-benzo[d]imidazole-4,7-diones exhibited the selective antiproliferative activity on the HUVECs. Further mechanistic study revealed that the inhibitory effect of one representative 1H-benzo[d]imidazole-4,7-dione 2b on HUVEC proliferation was mediated by the activation of p38 signaling pathway in the HUVECs. © 2006.
DOI
10.1016/j.bmc.2006.05.059
Appears in Collections:
약학대학 > 약학과 > Journal papers
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