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Blockade of peroxynitrite-mediated astrocyte death by manganese(III)-cyclam

Title
Blockade of peroxynitrite-mediated astrocyte death by manganese(III)-cyclam
Authors
Choi Y.Jin Y.Nam W.Kim H.-C.Kim W.-K.
Ewha Authors
남원우
SCOPUS Author ID
남원우scopus
Issue Date
2003
Journal Title
Neuroscience Research
ISSN
0168-0102JCR Link
Citation
vol. 45, no. 2, pp. 157 - 161
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Under glucose-deprived conditions, astrocytes rapidly underwent death due to their increased susceptibility to endogenously produced peroxynitrite (Gila 31, 155-164; J. Neuroimmunol. 112, 55-62; J. Neurochem. 74, 1989-1998). In the present study, the cell membrane-permeable synthetic superoxide dismutase (SOD) mimetic cyclam manganese(III) 1,4,8,11-tetraazacyclodecane (Mn(III)-cyclam) completely inhibited the death of glucose-deprived immunostimulated astrocytes. However, the structurally related compounds Ni(II)-cyclam, Co(II)-cyclam, and H 2-cyclam, which lacks metals, had no or a little cytoprotective effect. Of the cyclams used in this study, only Mn(III)-cyclam completely scavenged the peroxynitrite produced in glucose-deprived immunostimulated astrocytes and significantly blocked the depolarization of mitochondrial transmembrane potential in those cells. The present results suggest that cell membrane-permeable synthetic SOD mimetics such as Mn(III)-cyclam may be potential therapeutic agents for various diseases associated with the endogenous production of peroxynitrite. © 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
DOI
10.1016/S0168-0102(02)00206-7
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자연과학대학 > 화학·나노과학전공 > Journal papers
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