Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남원우 | * |
dc.date.accessioned | 2017-01-05T02:01:24Z | - |
dc.date.available | 2017-01-05T02:01:24Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0168-0102 | * |
dc.identifier.other | OAK-1355 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233744 | - |
dc.description.abstract | Under glucose-deprived conditions, astrocytes rapidly underwent death due to their increased susceptibility to endogenously produced peroxynitrite (Gila 31, 155-164; J. Neuroimmunol. 112, 55-62; J. Neurochem. 74, 1989-1998). In the present study, the cell membrane-permeable synthetic superoxide dismutase (SOD) mimetic cyclam manganese(III) 1,4,8,11-tetraazacyclodecane (Mn(III)-cyclam) completely inhibited the death of glucose-deprived immunostimulated astrocytes. However, the structurally related compounds Ni(II)-cyclam, Co(II)-cyclam, and H 2-cyclam, which lacks metals, had no or a little cytoprotective effect. Of the cyclams used in this study, only Mn(III)-cyclam completely scavenged the peroxynitrite produced in glucose-deprived immunostimulated astrocytes and significantly blocked the depolarization of mitochondrial transmembrane potential in those cells. The present results suggest that cell membrane-permeable synthetic SOD mimetics such as Mn(III)-cyclam may be potential therapeutic agents for various diseases associated with the endogenous production of peroxynitrite. © 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved. | * |
dc.language | English | * |
dc.title | Blockade of peroxynitrite-mediated astrocyte death by manganese(III)-cyclam | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 45 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 157 | * |
dc.relation.lastpage | 161 | * |
dc.relation.journaltitle | Neuroscience Research | * |
dc.identifier.doi | 10.1016/S0168-0102(02)00206-7 | * |
dc.identifier.wosid | WOS:000181121200003 | * |
dc.identifier.scopusid | 2-s2.0-0037304924 | * |
dc.author.google | Choi Y. | * |
dc.author.google | Jin Y. | * |
dc.author.google | Nam W. | * |
dc.author.google | Kim H.-C. | * |
dc.author.google | Kim W.-K. | * |
dc.contributor.scopusid | 남원우(7006569723) | * |
dc.date.modifydate | 20240116111857 | * |