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Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase Cγ
- Title
- Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase Cγ
- Authors
- Kang H.J.; Noh J.S.; Bae Y.S.; Gwag B.J.
- Ewha Authors
- 배윤수
- SCOPUS Author ID
- 배윤수
- Issue Date
- 2003
- Journal Title
- Molecular Pharmacology
- ISSN
- 0026-895X
- Citation
- Molecular Pharmacology vol. 64, no. 2, pp. 228 - 234
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We examined the possibility that the neuroprotective effects of Li + would depend upon the patterns of neuronal death, apoptosis versus necrosis, and whether Ca 2+ as well as phosphoinositide 3-kinase (PI3-K) would mediate the neuroprotective effect of Li +. Cortical neurons treated with Li + showed marked increase in [Ca 2+] i within 2 min. Addition of BAPTA-acetoxymethyl ester, a selective Ca 2+ chelator, abrogated the antiapoptotic effect of Li +. PI3-K was activated rapidly within 1 min after exposure to Li +, which mediated Ca 2+-dependent neuroprotective effects of Li +. Activated PI3-K seemed to increase [Ca 2+] i via the phospholipase Cγ (PLCγ) pathway. Antiapoptosis action of Li + was prevented in the presence of U-73122, a selective phospholipase C inhibitor, and was not observed in PLCγ1-null fibroblasts. In contrast to antiapoptosis action, administration of Li + did not prevent neuronal cell necrosis by excitotoxicity or free radicals. Li + selectively prevents apoptosis by increasing [Ca 2+] i through activation of PI3-K and PLCγ pathways.
- DOI
- 10.1124/mol.64.2.228
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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