Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배윤수 | * |
dc.date.accessioned | 2017-01-05T02:01:18Z | - |
dc.date.available | 2017-01-05T02:01:18Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0026-895X | * |
dc.identifier.other | OAK-1547 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233712 | - |
dc.description.abstract | We examined the possibility that the neuroprotective effects of Li + would depend upon the patterns of neuronal death, apoptosis versus necrosis, and whether Ca 2+ as well as phosphoinositide 3-kinase (PI3-K) would mediate the neuroprotective effect of Li +. Cortical neurons treated with Li + showed marked increase in [Ca 2+] i within 2 min. Addition of BAPTA-acetoxymethyl ester, a selective Ca 2+ chelator, abrogated the antiapoptotic effect of Li +. PI3-K was activated rapidly within 1 min after exposure to Li +, which mediated Ca 2+-dependent neuroprotective effects of Li +. Activated PI3-K seemed to increase [Ca 2+] i via the phospholipase Cγ (PLCγ) pathway. Antiapoptosis action of Li + was prevented in the presence of U-73122, a selective phospholipase C inhibitor, and was not observed in PLCγ1-null fibroblasts. In contrast to antiapoptosis action, administration of Li + did not prevent neuronal cell necrosis by excitotoxicity or free radicals. Li + selectively prevents apoptosis by increasing [Ca 2+] i through activation of PI3-K and PLCγ pathways. | * |
dc.language | English | * |
dc.title | Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase Cγ | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 64 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 228 | * |
dc.relation.lastpage | 234 | * |
dc.relation.journaltitle | Molecular Pharmacology | * |
dc.identifier.doi | 10.1124/mol.64.2.228 | * |
dc.identifier.wosid | WOS:000184220900006 | * |
dc.identifier.scopusid | 2-s2.0-0042343738 | * |
dc.author.google | Kang H.J. | * |
dc.author.google | Noh J.S. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Gwag B.J. | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.date.modifydate | 20240415133331 | * |