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Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase Cγ

Title
Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase Cγ
Authors
Kang H.J.Noh J.S.Bae Y.S.Gwag B.J.
Ewha Authors
배윤수
SCOPUS Author ID
배윤수scopus
Issue Date
2003
Journal Title
Molecular Pharmacology
ISSN
0026-895XJCR Link
Citation
vol. 64, no. 2, pp. 228 - 234
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We examined the possibility that the neuroprotective effects of Li + would depend upon the patterns of neuronal death, apoptosis versus necrosis, and whether Ca 2+ as well as phosphoinositide 3-kinase (PI3-K) would mediate the neuroprotective effect of Li +. Cortical neurons treated with Li + showed marked increase in [Ca 2+] i within 2 min. Addition of BAPTA-acetoxymethyl ester, a selective Ca 2+ chelator, abrogated the antiapoptotic effect of Li +. PI3-K was activated rapidly within 1 min after exposure to Li +, which mediated Ca 2+-dependent neuroprotective effects of Li +. Activated PI3-K seemed to increase [Ca 2+] i via the phospholipase Cγ (PLCγ) pathway. Antiapoptosis action of Li + was prevented in the presence of U-73122, a selective phospholipase C inhibitor, and was not observed in PLCγ1-null fibroblasts. In contrast to antiapoptosis action, administration of Li + did not prevent neuronal cell necrosis by excitotoxicity or free radicals. Li + selectively prevents apoptosis by increasing [Ca 2+] i through activation of PI3-K and PLCγ pathways.
DOI
10.1124/mol.64.2.228
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자연과학대학 > 생명과학전공 > Journal papers
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