View : 21 Download: 0

Synthesis of D- and L-apio nucleoside analogues with 2′-hydroxyl group as potential anti-HIV agents

Title
Synthesis of D- and L-apio nucleoside analogues with 2′-hydroxyl group as potential anti-HIV agents
Authors
Jin D.Z.Kwon S.H.Moon H.R.Gunaga P.Kim H.O.Kim D.-K.Chun M.W.Jeong L.S.
Ewha Authors
정낙신김대기
SCOPUS Author ID
김대기scopus
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 12, no. 5, pp. 1101 - 1109
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The present work describes the asymmetric synthesis of D- and L-apio-2′,3′-dideoxynucleoside analogues, 4 and 5 with 2′-hydroxyl group via a common intermediate 9, starting from D-galactose. Stereoselective dihydroxylation and deoxygenation through radical inversion were successfully employed to synthesize the key intermediate 12 with D-apio structure, while stereoselecetive hydroboration-oxidation was used for the synthesis of another key intermediate 18 with L-apio structure. © 2003 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2003.12.002
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE