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자연과학대학
생명과학전공
Journal papers
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SuPr-1-mediated desumoylation regulates the repressor activity of ΔNp63α
Title
SuPr-1-mediated desumoylation regulates the repressor activity of ΔNp63α
Authors
Lee H.-o.
;
Cho M.
;
Lee J.-H.
;
Kim H.-S.
;
Yun Y.
;
Lee H.
Ewha Authors
윤영대
SCOPUS Author ID
윤영대
Issue Date
2007
Journal Title
FEBS Letters
ISSN
0014-5793
Citation
FEBS Letters vol. 581, no. 29, pp. 5640 - 5644
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
ΔNp63α is exclusively expressed in stem cells and progenitor cells of the stratified epithelia. It promotes cell proliferation by antagonizing p53 and related TAp63/TAp73. Here, we report that specific desumoylation by SUMO protease SuPr-1 provides a fine-tuning mechanism for ΔNp63α repressor activity. We found that disrupting the sumoylation site compromised ΔNp63α repressor activity profoundly against TAp63γ and TAp73β-mediated transcription activation, but not to p53-mediated transcription. We further found that SuPr-1 specifically bound to sumoylated ΔNp63α and hydrolyzed SUMO. Consequently, SuPr-1 expression reduced ΔNp63α repressor activity to TAp63γ and TAp73β, whereas p53-mediated transactivation was unaffected. Collectively, these data suggest that SuPr-1-mediated ΔNp63α desumoylation elaborately regulates epithelial growth. © 2007 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2007.11.013
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