View : 28 Download: 0

SuPr-1-mediated desumoylation regulates the repressor activity of ΔNp63α

Title
SuPr-1-mediated desumoylation regulates the repressor activity of ΔNp63α
Authors
Lee H.-o.Cho M.Lee J.-H.Kim H.-S.Yun Y.Lee H.
Ewha Authors
윤영대
SCOPUS Author ID
윤영대scopus
Issue Date
2007
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 581, no. 29, pp. 5640 - 5644
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
ΔNp63α is exclusively expressed in stem cells and progenitor cells of the stratified epithelia. It promotes cell proliferation by antagonizing p53 and related TAp63/TAp73. Here, we report that specific desumoylation by SUMO protease SuPr-1 provides a fine-tuning mechanism for ΔNp63α repressor activity. We found that disrupting the sumoylation site compromised ΔNp63α repressor activity profoundly against TAp63γ and TAp73β-mediated transcription activation, but not to p53-mediated transcription. We further found that SuPr-1 specifically bound to sumoylated ΔNp63α and hydrolyzed SUMO. Consequently, SuPr-1 expression reduced ΔNp63α repressor activity to TAp63γ and TAp73β, whereas p53-mediated transactivation was unaffected. Collectively, these data suggest that SuPr-1-mediated ΔNp63α desumoylation elaborately regulates epithelial growth. © 2007 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2007.11.013
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE