Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤영대 | - |
dc.date.accessioned | 2017-01-05T02:01:03Z | - |
dc.date.available | 2017-01-05T02:01:03Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.other | OAK-4635 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233585 | - |
dc.description.abstract | ΔNp63α is exclusively expressed in stem cells and progenitor cells of the stratified epithelia. It promotes cell proliferation by antagonizing p53 and related TAp63/TAp73. Here, we report that specific desumoylation by SUMO protease SuPr-1 provides a fine-tuning mechanism for ΔNp63α repressor activity. We found that disrupting the sumoylation site compromised ΔNp63α repressor activity profoundly against TAp63γ and TAp73β-mediated transcription activation, but not to p53-mediated transcription. We further found that SuPr-1 specifically bound to sumoylated ΔNp63α and hydrolyzed SUMO. Consequently, SuPr-1 expression reduced ΔNp63α repressor activity to TAp63γ and TAp73β, whereas p53-mediated transactivation was unaffected. Collectively, these data suggest that SuPr-1-mediated ΔNp63α desumoylation elaborately regulates epithelial growth. © 2007 Federation of European Biochemical Societies. | - |
dc.language | English | - |
dc.title | SuPr-1-mediated desumoylation regulates the repressor activity of ΔNp63α | - |
dc.type | Article | - |
dc.relation.issue | 29 | - |
dc.relation.volume | 581 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 5640 | - |
dc.relation.lastpage | 5644 | - |
dc.relation.journaltitle | FEBS Letters | - |
dc.identifier.doi | 10.1016/j.febslet.2007.11.013 | - |
dc.identifier.wosid | WOS:000253488000016 | - |
dc.identifier.scopusid | 2-s2.0-36549066652 | - |
dc.author.google | Lee H.-o. | - |
dc.author.google | Cho M. | - |
dc.author.google | Lee J.-H. | - |
dc.author.google | Kim H.-S. | - |
dc.author.google | Yun Y. | - |
dc.author.google | Lee H. | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.date.modifydate | 20200901081003 | - |