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Tumor necrosis factor-α enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway

Title
Tumor necrosis factor-α enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway
Authors
Yu H.-N.Lee Y.-R.Noh E.-M.Lee K.-S.Song E.-K.Han M.-K.Lee Y.-C.Yim C.-Y.Park J.Kim B.-S.Lee S.-H.Lee S.J.Kim J.-S.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2008
Journal Title
International Journal of Hematology
ISSN
0925-5710JCR Link
Citation
vol. 87, no. 2, pp. 189 - 194
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The differentiation of promyelocytic leukemic cells into mature cells is the major strategy for drug-based treatment of leukemia. Higher efficient methods to differentiate promyelocytic leukemic cells have been developed using various differentiation inducers including interferon-α, interleukin-4, tumor necrosis factor-α (TNF-α), and dimethyl sulfoxide (DMSO) as a single agent or in combination with each other. Here, we show that a combination of TNF-α with DMSO shows a synergic effect on HL-60 cell differentiation through the activation of ERK pathway. TNF-α enhanced CD11b expression and percent of cell population in the G1 phase induced by DMSO, which are hallmarks for HL-60 cell differentiation. Inhibition of ERK pathway abolished the synergic effect of TNF-α in combination with DMSO on HL-60 differentiation, but the inhibition NF-κB pathway did not. These results suggest that TNF-α synergistically increases DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK-signaling pathway. © 2008 The Japanese Society of Hematology.
DOI
10.1007/s12185-008-0037-z
Appears in Collections:
약학대학 > 약학과 > Journal papers
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