Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2017-01-05T02:01:02Z | - |
dc.date.available | 2017-01-05T02:01:02Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.other | OAK-4649 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233576 | - |
dc.description.abstract | The differentiation of promyelocytic leukemic cells into mature cells is the major strategy for drug-based treatment of leukemia. Higher efficient methods to differentiate promyelocytic leukemic cells have been developed using various differentiation inducers including interferon-α, interleukin-4, tumor necrosis factor-α (TNF-α), and dimethyl sulfoxide (DMSO) as a single agent or in combination with each other. Here, we show that a combination of TNF-α with DMSO shows a synergic effect on HL-60 cell differentiation through the activation of ERK pathway. TNF-α enhanced CD11b expression and percent of cell population in the G1 phase induced by DMSO, which are hallmarks for HL-60 cell differentiation. Inhibition of ERK pathway abolished the synergic effect of TNF-α in combination with DMSO on HL-60 differentiation, but the inhibition NF-κB pathway did not. These results suggest that TNF-α synergistically increases DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK-signaling pathway. © 2008 The Japanese Society of Hematology. | - |
dc.language | English | - |
dc.title | Tumor necrosis factor-α enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 87 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 189 | - |
dc.relation.lastpage | 194 | - |
dc.relation.journaltitle | International Journal of Hematology | - |
dc.identifier.doi | 10.1007/s12185-008-0037-z | - |
dc.identifier.wosid | WOS:000253697200014 | - |
dc.identifier.scopusid | 2-s2.0-42049115249 | - |
dc.author.google | Yu H.-N. | - |
dc.author.google | Lee Y.-R. | - |
dc.author.google | Noh E.-M. | - |
dc.author.google | Lee K.-S. | - |
dc.author.google | Song E.-K. | - |
dc.author.google | Han M.-K. | - |
dc.author.google | Lee Y.-C. | - |
dc.author.google | Yim C.-Y. | - |
dc.author.google | Park J. | - |
dc.author.google | Kim B.-S. | - |
dc.author.google | Lee S.-H. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Kim J.-S. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |