Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2016-12-27T02:12:34Z | - |
dc.date.available | 2016-12-27T02:12:34Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 2072-6643 | * |
dc.identifier.other | OAK-19924 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233178 | - |
dc.description.abstract | Type 2 diabetes is a major public health concern worldwide. Xylobiose (XB) consists of two molecules of D-xylose and is a major disaccharide in xylooligosaccharides that are used as prebiotics. We hypothesized that XB could regulate diabetes-related metabolic and genetic changes via microRNA expression in db/db mice. For six weeks, C57BL/KsJ-db/db mice received 5% XB as part of the total sucrose content of their diet. XB supplementation improved glucose tolerance with reduced levels of OGTT AUC, fasting blood glucose, HbA1c, insulin, and HOMA-IR. Furthermore, XB supplementation decreased the levels of total triglycerides, total cholesterol, and LDL-C. The expression levels of miR-122a and miR-33a were higher and lower in the XB group, respectively. In the liver, expressions of the lipogenic genes, including, fatty acid synthase (FAS), peroxisome proliferator activated receptor γ (PPARγ), sterol regulatory element-binding protein-1C (SREBP-1C), sterol regulatory element-binding protein-2 (SREBP-2), acetyl-CoA carboxylase (ACC), HMG-CoA reductase (HMGCR), ATP-binding cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase (CYP7A1), and sterol 12-alpha-hydroxylase (CYP8B1), as well as oxidative stress markers, including superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2), glutathione peroxidase (GPX), and catalase, were also regulated by XB supplementation. XB supplementation inhibited the mRNA expressions levels of the pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1, as well as phosphorylation of c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK), p38 mitogen-activated protein kinases (MAPK), and extracellular signal-regulated kinases 1/2 (ERK1/2). These data demonstrate that XB exhibits anti-diabetic, hypolipogenic, and anti-inflammatory effects via regulation of the miR-122a/33a axis in db/db mice. © 2016 by the authors; licensee MDPI, Basel, Switzerland. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | db/db mice | * |
dc.subject | Inflammation | * |
dc.subject | Lipogenesis | * |
dc.subject | MicroRNA | * |
dc.subject | Xylobiose | * |
dc.title | Xylobiose, an alternative sweetener, ameliorates diabetes-related metabolic changes by regulating hepatic lipogenesis and miR-122a/33a in db/db Mice | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Nutrients | * |
dc.identifier.doi | 10.3390/nu8120791 | * |
dc.identifier.wosid | WOS:000389144100040 | * |
dc.identifier.scopusid | 2-s2.0-85003914655 | * |
dc.author.google | Lim E. | * |
dc.author.google | Lim J.Y. | * |
dc.author.google | Kim E. | * |
dc.author.google | Kim Y.-S. | * |
dc.author.google | Shin J.-H. | * |
dc.author.google | Seok P.R. | * |
dc.author.google | Jung S. | * |
dc.author.google | Yoo S.-H. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |