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Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy

Title
Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy
Authors
Chun H.S.Kim J.-M.Choi E.H.Chang N.
Ewha Authors
장남수
SCOPUS Author ID
장남수scopus
Issue Date
2008
Journal Title
Journal of Medicinal Food
ISSN
1096-620XJCR Link
Citation
vol. 11, no. 2, pp. 246 - 251
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The neuroprotective effect of six aqueous extracts and one alcoholic extract prepared from seven medicinal plants that have been recorded as having therapeutic effects for stroke in Korean traditional medicine were studied using both in vitro and in vivo cerebral ischemia models. Among the extracts tested, the aqueous extracts of Acorus gramineus, Chrysanthemum indicum, and Pinus densiflora and the alcoholic extract of Vitis vinifera significantly increased the cell viability of SK-N-SH human neuroblastoma cells exposed to oxygen-glucose deprivation (P < .05). Following two-vessel occlusion in gerbils, extracts of P. densiflora and V. vinifera significantly increased the number of surviving cells/mm2 of the CA1 region by 2.1-2.2-fold (P < .01). Oral or intraperitoneal administration of S-allyl cysteine, as a positive control, also markedly increased cell survival up to about 3.3-fold at the dosage of 300 mg/kg of body weight (P < .01). These results indicate that P. densiflora and V. vinifera exert neuroprotective effects against ischemic insults in both the in vitro and in vivo cerebral ischemia models and prompted us to further characterize the detailed mechanism of action and elucidate the active principles. © 2008 Mary Ann Liebert, Inc.
DOI
10.1089/jmf.2007.542
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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