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2,2-Dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties

Title
2,2-Dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties
Authors
Motiur Rahman A.F.M.Liang J.L.Lee S.H.Son J.K.Jung M.-J.Kwon Y.Jahng Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2008
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 31, no. 9, pp. 1087 - 1093
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The 2,2-dimethyl-2H-pyran-derived alkaloids acronycine and its demethylated congeners were prepared in three steps from anthranilic acid and phloroglucinol. The phenylboronic acid-mediated interamolecular cyclization reaction of 1,3-dihydroxyacridone and 3-methylbut-2-enal was employed as a key step, which was also applied to the synthesis of related cytotoxic benzo[b]acronycine. Inhibitory activities of the compounds prepared on topoisomerase I and II as well as their cytotoxicities were evaluated. Cytotoxicity of 2 is closely related to the strong inhibitory activity against topo II at 20 μM level. © 2008 The Pharmaceutical Society of Korea.
DOI
10.1007/s12272-001-1273-7
Appears in Collections:
약학대학 > 약학과 > Journal papers
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