Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-12-06T02:12:23Z | - |
dc.date.available | 2016-12-06T02:12:23Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-5067 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232995 | - |
dc.description.abstract | The 2,2-dimethyl-2H-pyran-derived alkaloids acronycine and its demethylated congeners were prepared in three steps from anthranilic acid and phloroglucinol. The phenylboronic acid-mediated interamolecular cyclization reaction of 1,3-dihydroxyacridone and 3-methylbut-2-enal was employed as a key step, which was also applied to the synthesis of related cytotoxic benzo[b]acronycine. Inhibitory activities of the compounds prepared on topoisomerase I and II as well as their cytotoxicities were evaluated. Cytotoxicity of 2 is closely related to the strong inhibitory activity against topo II at 20 μM level. © 2008 The Pharmaceutical Society of Korea. | * |
dc.language | English | * |
dc.title | 2,2-Dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1087 | * |
dc.relation.lastpage | 1093 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/s12272-001-1273-7 | * |
dc.identifier.wosid | WOS:000259364900002 | * |
dc.identifier.scopusid | 2-s2.0-52649092382 | * |
dc.author.google | Motiur Rahman A.F.M. | * |
dc.author.google | Liang J.L. | * |
dc.author.google | Lee S.H. | * |
dc.author.google | Son J.K. | * |
dc.author.google | Jung M.-J. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Jahng Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |