Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2016-12-06T02:12:22Z | - |
dc.date.available | 2016-12-06T02:12:22Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 1555-8932 | * |
dc.identifier.other | OAK-5087 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232984 | - |
dc.description.abstract | In this study, we investigated the lipolytic effects of eicosapentaenoic acid (EPA) in 3T3-L1 adipocytes. The differentiated 3T3-L1 adipocytes were treated in a serum-free medium with 300 μM of EPA for 3, 6, 12, and 24 h. In comparison with the control, intracellular lipid accumulation was significantly decreased by 24% at 24 h following the addition of EPA (P < 0.05). Under the same experimental conditions, there was an increase of glycerol and free fatty acids (FFAs). The mRNA level of carnitine palmitoyltransferase I-a, a component of the fatty-acid shuttle system involved in the mitochondrial oxidation of long-chain fatty acids, was also significantly elevated by EPA (P < 0.05). However, the expression of peroxisome proliferator-activated receptor-γ and acetyl-CoA carboxylase (ACC), which are involved in adipogenesis, was significantly down-regulated by EPA (P < 0.05). These results suggest that EPA may modulate lipid metabolism by stimulation of lipolysis, which was associated with induction of lipolytic gene expression and suppression of adipogenic gene expression in 3T3-L1 adipocytes. © Springer-Verlag 2007. | * |
dc.language | English | * |
dc.title | Eicosapentaenoic acid increases lipolysis through up-regulation of the lipolytic gene expression and down-regulation of the adipogenic gene expression in 3T3-L1 adipocytes | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 2 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 327 | * |
dc.relation.lastpage | 330 | * |
dc.relation.journaltitle | Genes and Nutrition | * |
dc.identifier.doi | 10.1007/s12263-007-0068-8 | * |
dc.identifier.wosid | WOS:000259604300005 | * |
dc.identifier.scopusid | 2-s2.0-41349114428 | * |
dc.author.google | Lee M.-S. | * |
dc.author.google | Kwun I.-S. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |