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자연과학대학
화학·나노과학전공
Journal papers
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Self-assembly of protein nanoarrays on block copolymer templates
Title
Self-assembly of protein nanoarrays on block copolymer templates
Authors
Lau K.H.A.
;
Bang J.
;
Kim D.H.
;
Knoll W.
Ewha Authors
김동하
SCOPUS Author ID
김동하
Issue Date
2008
Journal Title
Advanced Functional Materials
ISSN
1616-301X
Citation
Advanced Functional Materials vol. 18, no. 20, pp. 3148 - 3157
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
There is considerable interest in developing functional protein arrays on the nanoscale for high-throughput protein-based array technology, and for the study of biomolecular and cell interactions at the physical scale of the biomolecules. To these ends, self-assembly based techniques may be desirable for the nanopatterning of proteins on large sample areas without the use of lithography equipment. We present a fast, general approach for patterning proteins (and potentially other biomolecules) on the nanoscale, which takes advantage of the ability of block copolymers to self-assemble into ordered surface nanopatterns with defined chemical heterogeneity. We demonstrate nanoarrays of immunoglobulin and bovine serum albumin on polystyreneblock -poly(methyl methacrylate) templates, and illustrate the applicability of our technique through immunoassays and DNA sensing performed on the protein nanoarrays. Furthermore, we show that the pattern formation mechanism is a nanoscale effect originating from a combination of fluid flow forces and geometric restrictions templated by an underlying nanopattern with a difference in protein adsorption behavior on adjacent, chemically distinct surfaces. This understanding may provide a framework for extending the patterning approach to other proteins and material systems. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA.
DOI
10.1002/adfm.200800487
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