Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동하 | * |
dc.date.accessioned | 2016-11-30T02:11:33Z | - |
dc.date.available | 2016-11-30T02:11:33Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 1616-301X | * |
dc.identifier.other | OAK-5183 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232934 | - |
dc.description.abstract | There is considerable interest in developing functional protein arrays on the nanoscale for high-throughput protein-based array technology, and for the study of biomolecular and cell interactions at the physical scale of the biomolecules. To these ends, self-assembly based techniques may be desirable for the nanopatterning of proteins on large sample areas without the use of lithography equipment. We present a fast, general approach for patterning proteins (and potentially other biomolecules) on the nanoscale, which takes advantage of the ability of block copolymers to self-assemble into ordered surface nanopatterns with defined chemical heterogeneity. We demonstrate nanoarrays of immunoglobulin and bovine serum albumin on polystyreneblock -poly(methyl methacrylate) templates, and illustrate the applicability of our technique through immunoassays and DNA sensing performed on the protein nanoarrays. Furthermore, we show that the pattern formation mechanism is a nanoscale effect originating from a combination of fluid flow forces and geometric restrictions templated by an underlying nanopattern with a difference in protein adsorption behavior on adjacent, chemically distinct surfaces. This understanding may provide a framework for extending the patterning approach to other proteins and material systems. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA. | * |
dc.language | English | * |
dc.title | Self-assembly of protein nanoarrays on block copolymer templates | * |
dc.type | Article | * |
dc.relation.issue | 20 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3148 | * |
dc.relation.lastpage | 3157 | * |
dc.relation.journaltitle | Advanced Functional Materials | * |
dc.identifier.doi | 10.1002/adfm.200800487 | * |
dc.identifier.wosid | WOS:000260707300006 | * |
dc.identifier.scopusid | 2-s2.0-55349142167 | * |
dc.author.google | Lau K.H.A. | * |
dc.author.google | Bang J. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Knoll W. | * |
dc.contributor.scopusid | 김동하(26039227400) | * |
dc.date.modifydate | 20240123104500 | * |