View : 39 Download: 0

Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma

Title
Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma
Authors
Park J.W.Min H.J.Sohn J.H.Kim J.Y.Hong J.H.Sigrist K.S.Glimcher L.H.Hwang E.S.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2009
Journal Title
Journal of Allergy and Clinical Immunology
ISSN
0091-6749JCR Link
Citation
vol. 123, no. 2, pp. 479 - 485000000
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: A TH1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both TH1 and TH2 cytokines in TH cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce TH2 cytokines and have spontaneous airway inflammation. Objectives: We tested whether T-bet overexpression could protect against the development or progression of asthma. Methods: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. Results: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and TH2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as TH2 cytokine production. Conclusions: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma. © 2009 American Academy of Allergy, Asthma & Immunology.
DOI
10.1016/j.jaci.2008.10.035
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE