Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-10-20T02:10:39Z | - |
dc.date.available | 2016-10-20T02:10:39Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0091-6749 | * |
dc.identifier.other | OAK-5415 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232548 | - |
dc.description.abstract | Background: A TH1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both TH1 and TH2 cytokines in TH cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce TH2 cytokines and have spontaneous airway inflammation. Objectives: We tested whether T-bet overexpression could protect against the development or progression of asthma. Methods: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. Results: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and TH2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as TH2 cytokine production. Conclusions: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma. © 2009 American Academy of Allergy, Asthma & Immunology. | * |
dc.language | English | * |
dc.title | Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 123 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 479 | * |
dc.relation.lastpage | 485000000 | * |
dc.relation.journaltitle | Journal of Allergy and Clinical Immunology | * |
dc.identifier.doi | 10.1016/j.jaci.2008.10.035 | * |
dc.identifier.wosid | WOS:000263495000029 | * |
dc.identifier.scopusid | 2-s2.0-59449090710 | * |
dc.author.google | Park J.W. | * |
dc.author.google | Min H.J. | * |
dc.author.google | Sohn J.H. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Hong J.H. | * |
dc.author.google | Sigrist K.S. | * |
dc.author.google | Glimcher L.H. | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |