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Roles of ERK, PI3 kinase, and PLC-γ pathways induced by overexpression of translationally controlled tumor protein in HeLa cells

Title
Roles of ERK, PI3 kinase, and PLC-γ pathways induced by overexpression of translationally controlled tumor protein in HeLa cells
Authors
Kim M.Jung J.Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림scopus
Issue Date
2009
Journal Title
Archives of Biochemistry and Biophysics
ISSN
0003-9861JCR Link
Citation
vol. 485, no. 1, pp. 82 - 87
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We reported previously that translationally controlled tumor protein (TCTP) is a cytoplasmic repressor of Na,K-ATPase in HeLa cells. In the current study, we showed that TCTP overexpression using adenovirus as vehicle, induced partial inhibition of Na,K-ATPase; phosphorylation of EGFR tyrosine residues 845, 992, 1068, and 1148; activation of Ras/Raf/ERK pathway; activation of PI3K/Akt pathway; and phosphorylation of PLC-γ in HeLa cells. Specific inhibition of PI3K/Akt pathway in contrast to the inhibition of ERK, significantly decreased TCTP overexpression-induced survival signal. Inhibition of PLC-γ pathway significantly decreased TCTP overexpression-induced cell migration but inhibition of ERK had less effect. These results suggest that TCTP plays a key physiological role in cell survival through Akt pathway and migration through PLC-γ pathway. © 2009 Elsevier Inc. All rights reserved.
DOI
10.1016/j.abb.2009.02.002
Appears in Collections:
약학대학 > 약학과 > Journal papers
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