Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이경림 | * |
dc.date.accessioned | 2016-10-15T01:10:23Z | - |
dc.date.available | 2016-10-15T01:10:23Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0003-9861 | * |
dc.identifier.other | OAK-5595 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232415 | - |
dc.description.abstract | We reported previously that translationally controlled tumor protein (TCTP) is a cytoplasmic repressor of Na,K-ATPase in HeLa cells. In the current study, we showed that TCTP overexpression using adenovirus as vehicle, induced partial inhibition of Na,K-ATPase; phosphorylation of EGFR tyrosine residues 845, 992, 1068, and 1148; activation of Ras/Raf/ERK pathway; activation of PI3K/Akt pathway; and phosphorylation of PLC-γ in HeLa cells. Specific inhibition of PI3K/Akt pathway in contrast to the inhibition of ERK, significantly decreased TCTP overexpression-induced survival signal. Inhibition of PLC-γ pathway significantly decreased TCTP overexpression-induced cell migration but inhibition of ERK had less effect. These results suggest that TCTP plays a key physiological role in cell survival through Akt pathway and migration through PLC-γ pathway. © 2009 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Roles of ERK, PI3 kinase, and PLC-γ pathways induced by overexpression of translationally controlled tumor protein in HeLa cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 485 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 82 | * |
dc.relation.lastpage | 87 | * |
dc.relation.journaltitle | Archives of Biochemistry and Biophysics | * |
dc.identifier.doi | 10.1016/j.abb.2009.02.002 | * |
dc.identifier.wosid | WOS:000265754100012 | * |
dc.identifier.scopusid | 2-s2.0-64549105686 | * |
dc.author.google | Kim M. | * |
dc.author.google | Jung J. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.date.modifydate | 20240501081003 | * |