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Methylamine acts as excellent chemical trigger to Harden emulsion droplets into spongy PLGA microspheres

Title
Methylamine acts as excellent chemical trigger to Harden emulsion droplets into spongy PLGA microspheres
Authors
Kim, YuyoungKim, HansolSah, Hongkee
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2016
Journal Title
RSC ADVANCES
ISSN
2046-2069JCR Link
Citation
vol. 6, no. 88, pp. 85275 - 85284
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The purpose of this research was to produce porous sponge-like PLGA microspheres through a simple emulsion technique using a non-halogenated organic solvent and methylamine. In order to achieve this objective, a dispersed phase consisting of PLGA and methyl propionate was emulsified in an aqueous polyvinyl alcohol solution to produce an oil-in-water emulsion. When methylamine was added to the aqueous phase, it partitioned to the oil phase and reacted with methyl propionate to produce methanol and N-methyl propionamide. These water-soluble decomposition products acted as anti-solvents against PLGA. As they leached to the aqueous phase, oil droplets effectively hardened to sponge-like microspheres. This technique, utilizing a chemical reaction between the dispersed solvent and methylamine, has shown excellence compared to the existing water-in-oil-in-water emulsion techniques that require the help of porogens. For example, even without using porogens and high-shear/high-energy mixing devices, our simple technology made it possible to produce very porous microspheres with a sponge-like skeleton. Also, rather than using halogenated methylene chloride, which has been commonly used to produce microspheres, this new technique used methyl propionate, a non-halogenated and safer alternative. Furthermore, it enabled us to adjust the amount of residual methyl propionate in the microspheres below 0.5%, meeting the standard of residual organic solvents in microspheres set by regulatory authorities. The innovative technology reported in this study would make a large contribution to producing porous microspheres with the use of various hydrophobic polymers.
DOI
10.1039/c6ra17576g
Appears in Collections:
약학대학 > 약학과 > Journal papers
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